重度抑郁障碍与超眠症投诉:对非抑郁个体进行比较研究,检查客观生物标志物
Balthazar Bazin1, Justine Frija-Masson2, Helene Benzaquen3
1GHU Paris - Psychiatry & Neurosciences, 1 rue Cabanis, 75014 Paris, France.
Journal of affective disorders
|February 16, 2024
概括
患有高睡眠症和严重抑郁症 (MDD) 的患者准确估计了睡眠时间,并且客观证实了高睡眠症. 这项研究使用了多睡眠学和MSLT来描述这些患者的睡眠模式.
科学领域:
- 睡眠医学 睡眠医学
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 过度睡眠是主要抑郁症 (MDD) 的常见症状,与剧情严重程度的增加,自杀风险和抗抑郁药耐药性有关.
- 很少有研究利用多睡眠学 (PSG) 和多重睡眠延迟测试 (MSLT) 来调查MDD患者的超眠症.
- 这项研究比较了患有高睡眠症和MDD (HSC/MDD+) 的患者与患有高睡眠症但没有MDD (HSC/MDD-) 的患者.
研究的目的:
- 为了比较患者的客观和主观睡眠特征 超眠症和MDD与那些没有MDD的超眠症.
- 为了研究两组之间睡眠结构,睡眠延迟和睡眠持续时间估计的差异.
- 为了确定MDD是否影响客观的睡眠测量和超眠症诊断标准的满足.
主要方法:
- 采用了回顾性横截面研究设计.
- 参与者被分为两个组:HSC/MDD+和HSC/MDD-,使用DSM-5标准和CES-D尺度进行诊断.
- 两组都接受了30小时的PSG,随意睡眠,随后是MSLT.
主要成果:
- 与HSC/MDD-患者相比,HSC/MDD-患者在PSG上表现出明显更长的客观总睡眠时间 (oTST).
- HSC/MDD+患者表现出更准确的睡眠时间估计 (自我声明和客观TST之间的差异较小).
- 较高比例的HSC/MDD+患者满足了高睡眠症的客观标准 (oTST>10小时),并显示了减少REM睡眠延迟 (Kupfer指数).
- 两组都报告了类似的白天嗜睡程度 (爱普沃思尺度),但HSC/MDD+的短MSLT睡眠延迟较少.
结论:
- 患有高睡眠症和MDD (HSC/MDD+) 的患者可以准确估计他们的睡眠时间.
- 客观的多重睡眠学证实高睡眠症在HSC/MDD+患者中占比较高.
- HSC/MDD+患者可能表现出明显的睡眠模式,其特点是减少REM睡眠延迟.
相关概念视频
01:18Depression: Overview
244
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
244
01:27Depressive Disorders: MDD and Dysthymia
136
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
136
01:07Narcolepsy
102
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
102
01:11Understanding Sleep
228
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
228
01:27Depressive Disorders: Etiology
102
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
102
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
174
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
174