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在东南地区的退伍军人人口中发现帕杰特骨疾病
Mariana Urquiaga1, Angelo Gaffo1
1Birmingham VA Medical Center, Birmingham, Alabama, USA; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
The American journal of the medical sciences
|February 16, 2024
概括
页面页面是一个页面.
科学领域:
- 骨生物学 骨生物学 骨生物学
- 流行病学 流行病学
- 遗传学 是一个遗传学.
背景情况:
- 帕杰特骨疾病 (PDB) 的特点是骨重塑的加速.
- 传统上,PDB被认为在欧洲血统的人群中更为普遍.
- 临床观察表明,美国东南部退伍军人人口中,非洲裔美国人的患病率更高.
研究的目的:
- 调查美国东南部退伍军人人口中非洲裔美国人和白人患者中帕杰特骨病 (PDB) 的流行情况.
- 根据种族,比较PDB患者的人口和临床特征.
主要方法:
- 使用退伍军人事务的临床数据仓库 (CDW) 和电子医疗记录 (EMR) 的横截面研究.
- 从2000年到2020年,在伯明翰VA医疗中心 (BVAMC) 发现了患有帕杰特骨病 (PDB) 的患者.
- 对比了被诊断患有PDB的非洲裔美国人和白人患者的比例,并分析了诊断时的年龄和疾病特征.
主要成果:
- 在BVAMC (p = 0.0036) 中,非洲裔美国患者 (51%) 比白人患者 (40%) 更常见的帕杰特骨病 (PDB).
- 与白人患者 (平均70.1岁) 相比,非洲裔美国患者的诊断年龄明显较小 (平均为64.6岁) (p = 0.0009).
- 种族群体之间没有观察到性酸盐酸酶水平,多性病或症状并发症的显著差异.
结论:
- 在研究的美国东南地区退伍军人群中,帕杰特骨病 (PDB) 在非裔美国患者中比白人患者更为普遍.
- 研究结果表明,美国东南部的非洲裔美国人可能患有帕杰特骨病 (PDB).
- 进一步的研究是有必要的,以探索流行病学和潜在的遗传因素,导致PDB在这个人口.
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