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在椎间盘退行症中与低度毒性感染相关的危险因素:系统性审查和元分析

Mingtao Zhang¹, Jingwen Jia¹, Liangna Deng²

¹Department of Orthopaedics, Lanzhou University Second Hospital, No. 82 Cuiyingmen, Chengguan District, Lanzhou 730000, Gansu, China; Orthopaedics Key Laboratory of Gansu Province, No. 82 Cuiyingmen, Chengguan District, Lanzhou, Gansu, 730000, China.

The spine journal : official journal of the North American Spine Society

|February 16, 2024

概括

低度细菌感染,特别是Propionibacterium acnes (P. acnes),与椎间盘退化 (IDD) 有关. 关键的危险因素包括男性性别,莫迪克变化, sciatica 和年轻的年龄.

科学领域:

整形外科整形外科整形外科
传染性疾病传染性疾病
脊柱外科手术脊柱外科手术

背景情况:

新兴研究将低级细菌感染,特别是Propionibacterium acnes (P. acnes) 与椎间盘退化 (IDD) 联系起来.
以前的元分析没有系统地评估IDD中这些感染的风险因素.
本研究通过审查和分析文献来解决这一差距.

研究的目的:

在被诊断为IDD的患者中,系统地审查和评估与低度细菌感染相关的风险因素.
综合现有关于IDD细菌感染的流行率和特定风险因素的现有证据.

主要方法:

使用主要数据库 (PubMed,科学网,Embase,柯克伦图书馆) 进行了系统的文献审查.
包括符合条件的研究,确定IDD患者低度细菌感染的危险因素.
用随机或固定的效应模型进行了元分析,将33项涉及4109名患者的研究数据汇集在一起.

主要成果:

在IDD中,低度细菌感染的综合流行率为30%,其中P. acnes是最常见的病原体 (25%).
强有力的证据确定男性性别 (OR=2.15) 和Modic变化 (MCs) (OR=3.59) 是显著的风险因素.
适度的证据支持 sciatica (OR=2.31) 和年轻的年龄 (OR=-3.47) 作为危险因素.

结论:

椎间盘退化 (IDD) 和低度细菌感染之间存在显著的关联,主要是由P. acnes引起的.
在IDD患者中,这些感染的确定的风险因素包括男性性别,Modic变化,坐骨髓炎和年轻年龄.
进一步的研究可能会阐明更细微的关系,并完善临床管理策略.

关键词:

细菌细菌是一种细菌.在C. acnes的作品中.椎间盘退化椎间盘退化进行元分析分析.在P. acnes中.风险因素风险因素

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