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在ARDS中,progranulin通过AMPK/PGC-1α通路通过线粒体代谢促进调节性T细胞的可塑性

Yanqing Chen1, Minkang Guo2, Ke Xie3

  • 1Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; The Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Clinical immunology (Orlando, Fla.)
|February 16, 2024
PubMed
概括

进子素 (PGRN) 通过改善T细胞功能和减少年轻和老年患者的肺损伤,在治疗急性呼吸困扰综合征 (ARDS) 中表现有前途. 这种蛋白调节线粒体功能,有助于调节性T细胞 (Tregs) 的分化.

关键词:
急性呼吸应急综合征 (ARDS) 是一种急性呼吸应急综合征.免疫衰变的起源代谢重编程是一种代谢重编程.线粒体中的线粒体.进子素 (PGRN) 是一种监管性T细胞 (Tregs) 的使用

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