在青少年和年轻成年期同时接触多种金属和外部化症状之间的性别特异性关联
Kristie Oluyemi1, Elza Rechtman2, Azzurra Invernizzi2
1Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Nash Family Department of Neuroscience Icahn School of Medicine at Mount Sinai, New York NY, USA; The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Environmental research
|February 16, 2024
概括
暴露于金属与青少年男性的外部化症状增加有关,但与女性无关. 这表明,性别特定的脆弱性可能会导致心理健康差异在外部化障碍.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 外向化障碍在青少年转诊中很常见,并预测了以后的精神病理学.
- 男性比女性更频繁地表现出外部化障碍.
- 有限的研究探讨了性如何影响金属暴露和外部化症状之间的联系.
研究的目的:
- 调查多种金属的共同暴露与外部化症状之间的性别特定关联.
- 检查性对金属混合物和青少年和年轻成年人的外部化行为之间的关系的温和效应.
主要方法:
- 该研究包括来自意大利布雷西亚PHIME研究的150名青少年和年轻成年人 (15-25岁).
- 在血液,尿液,头发和唾液中测量了五种金属 (,,,铜,,).
- 使用ASEBA (YSR/ASR) 评估外部化症状,并分析了使用概括加权量子素和 (WQS) 回归的数据,并对共变量进行调整.
主要成果:
- 对金属混合物的暴露与男性与女性的攻击性行为有差异.
- 在男性中,暴露与更多的外部化问题,侵略性和侵入性行为 (由,铜,驱动) 有关.
- 在女性中,金属暴露和外部化症状之间没有发现显著的关联.
结论:
- 金属暴露对外化症状的影响因性别而异,男性更容易受到伤害.
- 在青少年时期对混合金属暴露的性别特异性脆弱性可能会导致精神健康障碍中观察到的性别差异.
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