农业活动和治疗甲状腺疾病的风险:来自TRACTOR项目的见解,这是一个全国性的队列研究
Pascal Petit1, Sylvain Chamot2, Abdallah Al-Salameh3
1CHU Grenoble Alpes, Centre Régional de Pathologies Professionnelles et Environnementales, 38000, Grenoble, France; Univ. Grenoble Alpes, AGEIS, 38000, Grenoble, France.
农业活动,特别是涉及牛的农业活动,与法国农场经理的甲状腺功能低下和甲状腺功能过高的风险增加有关. 这些发现强调了需要在农业环境中进行有针对性的监测和风险因素调查.
科学领域:
- 职业健康 职业健康 职业健康 职业健康
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 关于甲状腺疾病的流行病学数据有限,特别是在职业暴露的人群中.
- 法国农场经理 (FMs) 代表了研究职业甲状腺疾病风险的独特队列.
研究的目的:
- 研究特定农业活动与患甲状腺功能低下症和甲状腺功能过高症的风险之间的关联.
- 为了比较各种农业职业的甲状腺疾病风险,在法国大量的农民中.
主要方法:
- 利用来自法国行政数据库 (2002-2016) 的数字健康数据,用于超过100万个FM.
- 使用生存率分析来评估与26种农业活动相关的治疗甲状腺功能低下症和甲状腺功能过强症的危险比率 (HR).
- 调整了混因素,并进行了敏感性分析,以确保调查结果的可靠性.
主要成果:
- 牛养殖活动显示甲状腺功能增高 (HR 1.75-2.42) 和甲状腺功能低下 (HR 1.41-1.44) 的风险最高.
- 猪,家禽,养和果树种植的甲状腺功能低下风险也较高;与马相关的活动风险最低.
- 观察到显著的性别风险差异,男性奶牛农与女性相比,甲状腺功能障碍风险增加了两倍.
结论:
- 农业活动,特别是涉及牛的农业活动,与农场经理甲状腺疾病的风险增加有关.
- 甲状腺疾病的发展可能是多因素的,受"农业暴露体"的影响.
- 进一步研究特定的农业暴露,特别是与牛有关的暴露,对于改善农业中的甲状腺疾病监测至关重要.
更多相关视频
09:35Measurement of the Hand Transmitted Vibration of the Human Hand Arm System During Operation of a Hand Tractor
Published on: June 16, 2021
06:08Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
Published on: June 2, 2023
相关概念视频
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Functions of Thyroid Hormones
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Truncation in Survival Analysis
Left truncation occurs when individuals who experienced the event of interest before a certain time are not included in the study. This is often due to a "delayed entry" into the study where only those who survive until a certain entry point are...
