叶灰质体积增加及其与双相情感障碍的euthymic患者认知功能之间的关系
D Porta-Casteràs1, M Vicent-Gil2, M Serra-Blasco3
1Sant Pau Mental Health Research Group, Institut d'Investigació Biomèdica Sant Pau (IIB-SANT PAU), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Mental Health Department, Unitat de Neurociència Traslacional, Parc Tauli University Hospital, Institut d'Investigació i Innovació Sanitària Parc Taulí (I3PT), Barcelona, Spain; Department of Psychiatry and Forensic Medicine, School of Medicine Bellaterra, Universitat Autònoma de Barcelona, Barcelona, Spain.
Progress in neuro-psychopharmacology & biological psychiatry
|February 16, 2024
概括
缓解期的双极性障碍患者显示中枢叶体积增加,这可能表明大脑的弹性. 这些发现表明神经成像可能有助于管理双相情感障碍.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 大脑解剖学 大脑解剖学
背景情况:
- 双极性障碍 (BD) 具有情绪波动的特征,但许多患者在缓解期间会经历持久的认知缺陷.
- 以前的MRI研究表明,BD患者的大脑衰老加速,其证据是灰质体积减少.
- 这些大脑变化与BD认知功能之间的联系尚不清楚.
研究的目的:
- 通过使用多式成像技术,研究euthymic BD患者的神经结构变化和认知特征之间的关系.
- 为了比较BD患者和健康对照者的大脑结构 (HC).
- 探索大脑成像发现与认知表现之间的相关性.
主要方法:
- 27名高血压BD患者和24名高血压患者接受了结构性MRI和扩散权重成像 (DWI).
- 在BD患者中评估认知功能.
- 使用FreeSurfer估计了区域灰质量;分析了白质路径和扩散指标.
- 安科瓦模型比较了群体之间的大脑测量,皮尔森相关性检查了与认知领域的关系.
主要成果:
- 与HC相比,Euthymic BD患者的腹腔体积较高,左状和双边准海马回旋中的灰质体积增加,与HC相比.
- 在BD患者中,较高的灰质量与增强的执行功能相关.
结论:
- 中间叶体积升高的euthymicBD患者可能意味着大脑的弹性和认知适应.
- 这些发现突显了将神经成像纳入BD临床管理策略的潜力.
- 需要对更大,更多样化的样本进行进一步的研究来证实这些观察.
相关概念视频
01:30Bipolar Disorder
67
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
67
01:27Language and Cognition
346
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
346
01:24Mania and Antimanic Drugs: Overview
181
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
181