在Aβ阳性老年人中的非典型皮质层次结构及其反映在自发言语中
Rui He1, Jalal Al-Tamimi2, Gonzalo Sánchez-Benavides3
1Department of Translation & Language Sciences, Universitat Pompeu Fabra, 08018 Barcelona, Spain.
Brain research
|February 16, 2024
概括
阿尔茨海默病的风险,由粉样β (Aβ) 积累表明,显示早期的大脑在皮质层次和语言模式的变化,甚至在认知能力下降之前.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 疾病的生物标志物
背景情况:
- 异常的粉样β (Aβ) 沉积是阿尔茨海默病 (AD) 的早期标志物,在临床症状之前.
- 早期神经功能变化和行为读数的非侵入性检测在临床上是有益的.
研究的目的:
- 使用功能性MRI (fMRI) 调查与语音模式相关的皮层层次变化.
- 检查这些变化在认知不受损的老年人与或没有Aβ阳性.
主要方法:
- 从fMRI利用功能连接的大规模皮质梯度来绘制层次一体化的地图.
- 从自发言语中分析了声学-音特征.
- 对比Aβ阳性和Aβ阴性认知不受损的老年人 (N=188).
主要成果:
- 在Aβ阳性个体中证实了大大改变皮层层次和降低了变异性.
- 在Aβ阳性组中观察到量的增加.
- 发现了梯度变化,体测量和工作记忆 (数字跨度测试) 之间的相关性.
结论:
- 在临床AD诊断之前,Aβ积累与皮质层次的神经功能变化有关.
- 这些变化与语言模式和工作记忆的改变有关.
- 通过非侵入性神经成像和语音分析,可以早期发现AD风险.
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