对退伍军人同时出现物质使用障碍和PTSD的书面暴露疗法:随机临床试验的研究设计
Sarah Meshberg-Cohen1, Joan M Cook2, Amirah Bin-Mahfouz1
1Yale University School of Medicine, Department of Psychiatry, United States of America; VA Connecticut Healthcare System, United States of America.
Contemporary clinical trials
|February 16, 2024
概括
书面暴露疗法 (WET) 可以有效地减少退伍军人的创伤后应激障碍 (PTSD) 和物质使用障碍 (SUD) 症状. 这项研究将WET加常规治疗 (TAU) 与TAU进行比较,并对患有PTSD和SUD并发症的退伍军人进行中性写作任务.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 公共卫生 公共卫生
背景情况:
- 在退伍军人中,高水平的创伤后应激障碍 (PTSD) 与物质使用障碍 (SUD) 并存.
- 传统的SUD治疗方法往往忽略了PTSD,尽管有证据表明创伤知情护理可以改善伴随疾病的结果.
- 书面暴露疗法 (WET) 是一种简短,易于使用的PTSD心理治疗方法,患者满意度高,学率低于其他基于证据的心理治疗 (EBP).
研究的目的:
- 评估WET作为常规治疗 (TAU) 的辅助疗法的有效性,用于患有并发性PTSD和SUD的退伍军人.
- 为了比较TAU加WET与TAU加中性写作条件对PTSD和SUD症状的结果.
- 为了探索心率变化和治疗结果之间的联系,在这个人群中.
主要方法:
- 一个随机临床试验设计,将TAU+WET (n=51) 与TAU+中性写作 (n=51) 进行比较.
- 参与者是寻求治疗的退伍军人,患有并发性PTSD和SUD.
- 在基线,治疗后,以及在8周和12周的随访期间进行的评估.
主要成果:
- 主要假设:TAU+WET与TAU+中性写作相比,会显著减少PTSD症状.
- 二次假设:TAU+WET将导致更大减少物质使用日.
- 探索性分析将检查心率变化作为潜在的生物标志物.
结论:
- WET显示承诺作为一个简短的,容易传播的干预措施,为退伍军人与伴随性PTSD和SUD.
- 这些发现可以支持将WET纳入标准SUD治疗方案.
- 成功的结果将倡导WET作为这种服务不足的人群的有效辅助疗法.
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