风湿性关节炎是否会增加COPD的风险? :一个全国性的回顾性队列研究
Chiwook Chung1, Hyungjin Kim2, Kyungdo Han3
1Department of Pulmonary and Critical Care Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung.
Chest
|February 16, 2024
概括
类风湿性关节炎 (RA) 显著增加患慢性阻塞性肺病 (COPD) 的风险. 血清阳性RA比血清阴性RA具有更高的COPD风险,突出了RA患者呼吸系统监测的必要性.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 类风湿性关节炎 (RA) 是一种全身性炎症性疾病,已知肺部表现,主要是间歇性肺部疾病.
- RA 和慢性阻塞性肺病 (COPD) 都是慢性炎症状况,表明潜在的共享途径或增加风险.
研究的目的:
- 调查类风湿性关节炎 (RA) 是否增加患慢性阻塞性肺病 (COPD) 的风险.
- 为了确定是否存在血清阳性和血清阴性RA患者之间COPD风险的差异.
主要方法:
- 一项基于人口的队列研究,使用韩国国家医疗保险数据库.
- 鉴定了46,030名RA患者 (血清阳性和血清阴性) 和230,150名对照,从2010年到2019年进行监测.
- 多变量Cox比例危险模型被用于计算COPD发展的调整危险比率 (aHR).
主要成果:
- 与对照组相比,RA患者患上COPD的风险增加了2.11倍 (aHR,2.11;95% CI,1.96-2.28).
- 血清阳性和血清阴性RA都增加了COPD风险,而血清阳性RA显示出更高的风险 (aHR,1.26;95% CI,1.09至1.46).
- 吸烟史在COPD发展中与RA没有显著的相互作用.
结论:
- 类风湿性关节炎与COPD发展的风险增加有关.
- 血清阳性进一步增加了 RA 患者的 COPD 风险.
- 临床医生应密切监测RA患者的呼吸系统症状和肺功能.
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