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脂质介导蛋白质冠状体调节与增加的阿波利波蛋白AI招募质瘤向球瘤

Yiwei Zhang¹, Wei Xiao¹, Siqin He¹

¹Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

Journal of controlled release : official journal of the Controlled Release Society

|February 16, 2024

概括

具有增加阿波利波蛋白AI吸附性的工程纳米颗粒显示了增强的质瘤向. 这种新的方法使用大豆酸丁胆和聚 (DL-乳酸-co-glycolide) 纳米颗粒改善药物输送,并延长结质瘤携带小鼠的生存期.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
药物运输药物运输药物运输

背景情况:

纳米颗粒上的蛋白质冠状形成可以阻碍向药物输送.
功能性蛋白质吸附可以被设计成增强纳米颗粒准能力.

研究的目的:

开发阿波利波蛋白A-I增强纳米颗粒 (SPC-PLGA NPs) 以改善质瘤向.
为了研究大豆酸胆 (SPC) 在蛋白质冠状形成和准效率中的作用.

主要方法:

使用FDA批准的材料制造SPC-PLGANP.
在纳米粒子表面上对阿波利波蛋白AI吸附的量化.
在体外和体内评估质瘤向能力通过拾尸体受体类BI结合.
评估带有帕克利塔塞尔的SPC-PLGANP在减少结质瘤入侵和延长存活时间方面的有效性.

主要成果:

与对照纳米颗粒相比,SPC-PLGA NPs在蛋白质冠冕中显示出2.19倍高的阿波利波蛋白AI百分比.
观察到血液-大脑屏障和质瘤细胞上对食尸体受体类BI的增强结合.
用帕克利塔塞尔装载的SPC-PLGANP显示,显著减少了质瘤入侵.
用SPC-PLGANP治疗延长了带质瘤的小鼠的生存时间.

结论:

工程化蛋白质冠状体调节,特别是增加阿波利波蛋白AI吸附,可以显著提高纳米颗粒向质瘤的目标.
SPC-PLGA NPs代表了针对质瘤药物供应的有希望的战略.
这项研究为设计基于蛋白质冠状元调节的向药物递送系统提供了新的方向.

关键词:

在阿波利波蛋白A-I.针对大脑的目标定位瘤向向瘤的目标是脂质脂质是一种蛋白质冠状病毒病毒

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