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代谢障碍和中央执行网络的功能障碍在最小的肝脑病变中

Qiu-Yi Dong¹, Yun-Bin Cao¹, Hui-Wei Huang¹

¹Department of Radiology, Fujian Medical University Union Hospital, Fuzhou 350001, China.

Cerebral cortex (New York, N.Y. : 1991)

|February 16, 2024

概括

最小的肝脑病变会破坏大脑的中央执行网络,影响认知功能,并显示与代谢变化的联系. 这些大脑网络的变化可能有助于诊断这种情况.

科学领域:

神经科学是一个神经科学.
放射学放射学是一门学科.
代谢医学是一种代谢医学.

背景情况:

最小肝脑病变 (MHE) 是肝硬化的一种亚临床神经学并发症.
在MHE的认知障碍与大脑代谢障碍有关.
在MHE的中央执行网络 (CEN) 中,动态功能连接的作用仍然不清楚.

研究的目的:

研究MHE患者中CEN中的动态功能障碍.
确定这些动态功能变化,代谢障碍和MHE认知障碍之间的关联.
为了确定MHE诊断的潜在成像生物标志物.

主要方法:

使用静止状态功能磁共振成像 (rs-fMRI) 和磁共振光谱 (MRS).
分析了CEN的动态功能连接 (dFC) 使用滑动窗口方法和K-means集群.
通过心理计量肝脏脑病症得分评估右脊侧前额皮层 (rDLPFC) 的代谢物比率和神经认知性能.

主要成果:

与对照组相比,MHE患者表现出改变的rDLPFC代谢物比率 (减少MYO/Cr,CHO/Cr;增加Glx/Cr).
在MHE患者中观察到CEN内的静态功能连接性下降.
在MHE患者中发现低连接功能状态 (状态-1) 的频率和持续时间增加,与代谢和认知缺陷相关.

结论:

在MHE中存在CEN中的动态功能障碍,并且与rDLPFC中的代谢变化有关.
这些动态功能变化与MHE的认知障碍严重程度有显著的相关性.
rDLPFC代谢物比率 (MYO/Cr) 和状态-1中平均停留时间显示为MHE的诊断生物标志物具有前途.

关键词:

中央执行网络的中央执行网络动态功能连接的功能连接.磁共振光谱学磁共振光谱学最小的肝脏脑病变 - 肝脏脑病变.静止状态的功能磁共振成像技术

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