环境空气污染对肥胖和子宫外脂肪沉积的影响:系统审查和元分析的议定书
Mehnaz Munir1, Sandi M Azab2,3, Shrikant I Bangdiwala4,5
1Department of Global Health, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada.
BMJ open
|February 16, 2024
概括
空气污染可能会影响肥胖和相关的健康问题,如脂肪肝疾病. 本系统性审查和元分析研究了成年人空气质量与体重之间的联系.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 代谢疾病 代谢疾病
背景情况:
- 自1975年以来,全球肥胖率增加了三倍,这对公众健康构成了重大挑战.
- 新出现的证据表明,空气污染可能通过氧化应激和脂肪组织炎症影响肥胖.
- 空气污染对人体体重的影响仍然不确定.
研究的目的:
- 系统地审查和元分析环境空气污染与肥胖之间的关联.
- 检查空气污染和子宫外脂肪组织分布之间的关系.
- 评估空气污染对成年人非酒精性脂肪肝病的发病率和流行率的影响.
主要方法:
- 遵守系统审查和元分析 (PRISMA) 准则的首选报告项目.
- 在多个数据库 (Ovid Medline,Embase,PubMed,Web of Science,LILACS) 和灰色文学中进行全面的文献搜索.
- 使用DerSimonian和Laird随机效应模型进行数据提取和分析,以I2统计和GRADE的证据质量来评估异质性.
主要成果:
- 这个部分在研究完成后要填写.
结论:
- 这个部分在研究完成后要填写.
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