自体主导多囊性病患者的死亡风险
Deirdre Mladsi1, Xiaolei Zhou2, Gregory Mader2
1RTI Health Solutions, Research Triangle Park, NC, USA. dmladsi@rti.org.
BMC nephrology
|February 16, 2024
概括
自体主导多囊性病 (ADPKD) 患者的死亡率显示,患有末期病 (ESRD) 患者的风险更高,并突出了老年人的种族差异. 该研究为美国提供了关键的ADPKD死亡率数据.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 自体主导多囊性病 (ADPKD) 是末期病 (ESRD) 的主要遗传原因.
- 对ADPKD患者的特定死亡率数据有限.
- 这项研究旨在量化ADPKD患者队列中的死亡率.
研究的目的:
- 为了估计ADPKD患者的死亡率.
- 分析基于年龄,性别,种族和疾病阶段 (非ESRDCKD与ESRD) 的死亡率变化.
- 为了确定65岁及以上的ADPKD患者的特定死亡风险.
主要方法:
- 2014-2016年美国脏数据系统 (USRDS) 的分析.
- 包括患有非ESRD慢性病 (CKD) 和ESRD的队列.
- 使用考克斯回归计算死亡率和调整的危险比率,按人口统计和疾病特征分层.
主要成果:
- 包括1936名非ESRD慢性瘤患者和37461名ESRDADPKD患者.
- 年龄调整后的死亡率为18.4/1000患者年 (非ESRD CKD) 和37.4/1000患者年 (ESRD).
- 在晚期CKD和透析患者与移植受体之间观察到更高的死亡风险. 在≥65.5岁患者的死亡率中发现了显著的种族差异.
结论:
- 特定于ADPKD患者的死亡率,特别是65岁及以上的患者,表明种族差异.
- 这些发现解决了理解美国ADPKD特异性死亡率的关键差距.
- 数据突出显示了CKD各个阶段和ESRD治疗方式之间的死亡风险差异.
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