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Updated: Jul 2, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
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Published on: February 15, 2016

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作为DHFR和CDK2抑制剂的新型四化诺:合成,表征,抗癌活性和抗氧化特性

Eman M Sayed1, Etify A Bakhite2, Reda Hassanien3

  • 1Department of Chemistry, Faculty of Science, New Valley University, El-Kharja, 72511, Egypt. Emanmohsen@sci.nvu.edu.eg.

BMC chemistry
|February 16, 2024
PubMed
概括

新的抗癌药物四化类和四化[2,3-c]类,对肺癌和乳腺癌细胞表现出强烈的活性. 化合物7e抑制CDK2,化合物8d抑制DHFR,显示出双重抗癌和抗氧化能力.

关键词:
它们是抗癌的.抗氧化剂 抗氧化剂是一种抗氧化剂.细胞灭亡 (apoptosis) 是一种死亡的过程.这是一种CDK2抑制剂.细胞循环停止 细胞循环停止这是一种DHFR抑制剂.四化异类氨酸 (Tetrahydroisoquinolines) 是一种含有四化异类氨酸的化合物.四氨基[2,3-c]异类素.

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