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Updated: Jul 2, 2025

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

一个微流体平台整合了功能性血管化的芯片上的有机体.

Clément Quintard^1,2,3, Emily Tubbs¹, Gustav Jonsson^4,5,6

¹Univ. Grenoble Alpes, CEA, IRIG/BGE, BIOMICS, 38000, Grenoble, France.

Nature communications

|February 16, 2024

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概括

研究人员开发了一种新的微流体平台,以血管化芯片上的有机体,增强其生长和功能. 这一突破可以为先进的组织工程应用提供更好的3D组织培养和有机体 perfusion.

科学领域:

组织工程是组织工程.
微流体学微流体学
干细胞生物学干细胞生物学

背景情况:

像有机体这样的三维细胞培养的血管化对于长期组织工程至关重要.
现有的微流体设备往往无法复制体内流体的复杂性,并且需要复杂的设置.
芯片上有机体的血管化仍然是该领域的一个重大挑战.

研究的目的:

开发和评估一种新的微流体平台,用于在各种3D细胞聚合物周围建立和监测内皮细胞网络.
评估这些工程血管网络的功能整合和 perfusion 能力.
研究芯片上血管化的对有机体生长,成熟和功能的影响.

主要方法:

开发一个微流体平台,旨在支持内皮细胞网络的形成.
内皮细胞网络与介质细胞球体,胰腺小岛球体和干细胞衍生的血管器官体共同培养.
长期 (长达30天) 监测微生理系统内的网络形成和 perfusion.
在血管化后评估有机体生长,成熟和功能.

主要成果:

在各种球体和血管器官周围成功建立了内皮细胞网络.
证明了培养的3D组织的功能性血管内 perfusion.

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Published on: October 20, 2018

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Published on: May 5, 2022

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Published on: March 2, 2020

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Published on: October 20, 2018

由于血管化方法,有机体生长,成熟和整体功能显著增强.

这些工程网络与富含内皮质的球体和血管器官形成了功能性连接.

结论:

开发的微流体平台为在芯片上血管化各种生物3D组织提供了可行的解决方案.
该系统有效地支持有机体 perfusion,提高其可行性和功能.
该研究推进了芯片上的有机体领域,为组织工程提供了更具生理相关性的微环境.