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环境空气污染物和乳腺癌的阶段在德黑兰,伊朗

Zahra Khorrami¹, Mohsen Pourkhosravani², Ali Karamoozian³

¹Ophthalmic Epidemiology Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Scientific reports

|February 16, 2024

概括

暴露于空气污染,包括和等特定化学物质,与更先进的乳腺癌 (BC) 阶段有关. 这种风险在50岁以下的妇女和社会经济地位较低的妇女中尤为高.

科学领域:

环境健康环境健康
在瘤学瘤学.
流行病学流行病学

背景情况:

空气污染 (AP) 是一个全球性问题,具有潜在的健康影响.
乳腺癌 (BC) 是一个重要的公共卫生问题,特别是在女性中.
了解BC严重性的环境风险因素对于预防和早期检测至关重要.

研究的目的:

调查暴露于单个和多个空气污染物和诊断时乳腺癌的阶段之间的联系.
确定可能影响乳腺癌严重程度的特定空气污染物.
根据社会经济地位和年龄,探索AP暴露和BC阶段的潜在差异.

主要方法:

利用了2008-2016年期间在伊朗德黑兰诊断的1148例乳腺癌病例的数据.
从土地利用回归模型中获得的空气污染物数据 (PM10,SO2,NO,NO2,NOx,,,,乙烯,西,BTEX).
使用多项物流回归来评估空气污染物与乳腺癌阶段之间的关联.

主要成果:

对乙基,o-烯,m-烯和NO的暴露增加与I期乳腺癌的更高几率相关.
与非侵入性阶段相比,和o-xylen暴露与第三阶段和第四阶段乳腺癌的几率增加有关.
低社会经济水平地区的妇女患有I阶段或III和IV阶段的乳腺癌,其,乙和基含量较高.
对多种空气污染物的高暴露与50岁以下妇女患I期乳腺癌的可能性更高有关.

结论:

暴露于特定的空气污染物与诊断时乳腺癌阶段的增加有关.
这些发现突出了乳腺癌严重程度的潜在环境因素.
该研究强调了年轻女性 (50岁以下) 和社会经济地位较低的女性的风险增加,表明需要有针对性的公共卫生干预措施.

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