阿克尔曼西亚尼菲拉诱导的训练有素免疫表型增加了细菌细胞内生存率并减轻了炎症
Ainize Peña-Cearra1,2,3, Ainhoa Palacios1, Aize Pellon1,3
1Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Spain.
Communications biology
|February 16, 2024
概括
像A. muciniphila这样的共生细菌可以训练先天性免疫细胞,增强细菌的生存能力并减少炎症信号. 这表明肠道微生物在调节长期免疫反应方面发挥了作用,并突出了A. muciniphila的抗炎潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 肠道微生物组研究研究
背景情况:
- 天生的免疫细胞可以通过初次接触病原体或共生细胞来训练,从而影响后续反应.
- 肠道共生动物诱导训练免疫的机制尚不清楚.
- 阿克尔曼西亚 (Akkermansia muciniphila) 是一种肠道共生菌,在宿主-微生物相互作用中具有潜在的作用.
研究的目的:
- 调查A. muciniphila诱导巨细胞训练免疫的机制.
- 为了确定A. muciniphila对巨细胞对二次细菌挑战的反应的影响.
- 探索A. muciniphila. 的抗炎和益生菌潜力.
主要方法:
- 巨细胞被活生生的A. muciniphila入.
- 评估了巨细胞的反应,包括细菌存活率和细胞因子 (TNF,IL-10) 的产生.
- 在二次细菌暴露后进行了全球转录分析.
主要成果:
- 用A. muciniphila进行化,提高了巨细胞内的细菌的细胞内生存率.
- 支持和抗炎性细胞因子的释放 (TNF,IL-10) 在A. muciniphila原始化后减少.
- 转录分析显示,细胞和代谢基因的表达增加,同时降低杀死细菌和促炎基因的调节.
结论:
- A. muciniphila可以诱导巨细胞的训练免疫力,其特点是改变炎症信号和增强的细胞能力.
- 这些发现突出了特定肠道共生体在调节长期先天免疫反应中的作用.
- A. muciniphila 显示出作为一种抗炎益生菌剂的潜力.
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