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Updated: Jul 2, 2025

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需要SEL1L-HRD1相互作用才能形成一个功能性的HRD1 ERAD复合体

Liangguang Leo Lin1, Huilun Helen Wang1, Brent Pederson2

  • 1Department of Molecular Physiology and Biological Physics, University of Virginia, School of Medicine, Charlottesville, VA, 22903, USA.

Nature communications
|February 16, 2024
PubMed
概括

一种致病性SEL1L突变通过破坏ERAD复合体,在小鼠中引起部分胚胎致死性和动脉缩. 这突出了SEL1L的特点.

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