标志着猪肠微生物群的核心微生物群和调节功能
Jun Hu1,2,3, Jianwei Chen4,5, Libao Ma1,2,3
1National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Frontiers Science Center for Animal Breeding and Sustainable Production, College of Animal Sciences and Technology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
The ISME journal
|February 17, 2024
概括
研究人员对猪肠道微生物群进行了表征,确定了三个核心微生物. 这些微生物增强了无菌小鼠的宿主免疫力和新陈代谢,为猪肠微生物功能提供了洞察力.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 肠道微生物群在主体营养,新陈代谢和家庭猪 (Sus scrofa) 的免疫力方面发挥着至关重要的作用,这是一种主要的肉类生产动物.
- 了解猪肠微生物的结构和功能对于改善宿主微生物相互作用和利用微生物资源至关重要.
研究的目的:
- 为了全面研究七种猪品种的肠道微生物组.
- 建立猪肠微生物基因的参考目录,并确定新的元基因组组装基因组.
- 分析肠道抗体,并确定核心占主导地位的肠道微生物及其对宿主的功能影响.
主要方法:
- 利用元基因组学和16S rRNA基因扩增序列测序来分析七种猪品种的肠道微生物组.
- 建立了一个扩展的肠道微生物参考目录 (17,020,160个基因) 并确定了4910个元基因组组装基因组.
- 向没有细菌的小鼠注射了三种已识别的核心微生物 (Phascolarctobacterium succinatutens,Prevotella copri,Oscillibacter valericigenes),以评估它们的影响.
主要成果:
- 确定了三种核心占主导地位的肠道微生物:Phascolarctobacterium succinatutens,Prevotella copri和Oscillibacter valericigenes. 这些微生物主要存在于肠道中.
- 通过口服这些核心微生物增加了器官指数 (心脏,脏,胸腺) 并增强了无菌小鼠的肠上皮质屏障功能.
- 观察到主体代谢途径的显著改变,包括类固醇激素生物合成和胆酸生物合成,在核心微生物的管理后.
结论:
- 提供了猪肠微生物组组成和功能潜力的详细概述.
- 突出了特定核心肠道微生物对宿主器官发育,肠道健康和新陈代谢的重大影响.
- 提供了对猪关键肠道微生物的功能作用有价值的见解,对动物生产和健康有影响.
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