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Updated: May 11, 2026

Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus
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全球传播的是携带 optrA 的抗线索利德菌 Enterococcus faecalis ST476 克隆系

Andrea Brenciani1, Marzia Cinthi2, Sonia Nina Coccitto1

  • 1Department of Biomedical Sciences and Public Health, Unit of Microbiology, Polytechnic University of Marche Medical School, Ancona, Italy.

The Journal of antimicrobial chemotherapy
|February 17, 2024
PubMed
概括

全球分布的Enterococcus faecalis ST476系携带 optrA,赋予了对线胺的耐药性. 这种新兴的克隆,在人类,动物和环境来源中发现,需要一个健康的方法来管理其传播和进化.

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Antibiotic Selection

Overview
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Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
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Clinical Significance of Antibiotic Resistance

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