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增长/分化因子15控制了V-SVZ中的表皮细胞和干细胞数量

Katja Baur¹, Carmen Carrillo-García¹, Şeydanur Şan²

¹Department of Neurobiology, Interdisciplinary Center for Neurosciences (IZN), University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany.

Stem cell reports

|February 17, 2024

概括

增长/分化因子15 (GDF15) 调节神经干细胞在质突起中的增殖. 消去GDF15会增加细胞分裂,影响表皮细胞和神经干细胞.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
细胞生物学细胞生物学

背景情况:

发育/分化因子15 (GDF15) 表达在神经发育晚期的质突出 (GE) 中升高,特别是在神经干细胞 (NSC) 中.
在GE中GDF15的精确功能在很大程度上仍然未被描述.

研究的目的:

研究GDF15在调节细胞增殖和发展中的作用.
阐明GDF15在神经干细胞中的功能背后的分子机制.

主要方法:

在GE中对GDF15受体表达的分析.
在胚胎和成人模型中进行GDF15切除.
评估细胞增殖,细胞分裂和细胞命运.
研究GDF15与表皮生长因子受体 (EGFR) 信号的相互作用.

主要成果:

在GE中,GDF15受体的表达是亚皮性表达的.
GDF15切除增强了胚胎GE和成人心室子心室区 (V-SVZ) 的增殖和细胞分裂.
这导致过渡性神经发生,并持续增加表皮细胞和角NSCs.
GDF15信号影响EGFR信号通路.

结论:

GDF15在控制基因转基因中尖端祖先的扩散方面发挥着至关重要的作用.
GDF15的信号传递会影响表皮细胞和神经干细胞的恒常状态.
GDF15通过EGFR信号作用来调节原生细胞数量.

关键词:

在CXCR4中,CXCR4是最常见的.欧洲农业基金会 (EGFR) 是一个基金.在GDF15中,GDF15是GDF15中的一个.在GFRAL中,GFRAL是GFRAL的一部分.关节性突出突出是什么神经干细胞的神经干细胞辐射性质细胞亚皮性原始体的祖先

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