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Updated: May 1, 2026

Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis
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针对14-3-3θ介导的TDP-43病理在肌缩性侧面硬化和前性痴呆症小鼠中

Yazi D Ke1, Annika van Hummel1, Carol Au1

  • 1Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia.

Neuron
|February 17, 2024
PubMed
概括

研究人员发现14-3-3θ蛋白调解了TAR结合蛋白43 (TDP-43) 到细胞质的移动,这是肌缩侧硬化症 (ALS) 和前性痴呆症 (FTD) 的关键事件. 针对这种相互作用的基因疗法在ALS/FTD小鼠模型中显示出有前途.

关键词:
14-3-3 这是一个很好的时刻.在TDP-43中使用.骨髓缩侧面硬化症 (ALS) 是一种前性痴呆症前性痴呆症基因治疗的基因疗法鼠标模型 鼠标模型鼠标模型

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