相关实验视频
Updated: Jul 2, 2025

12:08
Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
18.8K
商用自动化胰岛素输送与开源自动化胰岛素输送系统在1型糖尿病中的回顾性比较
Anna Schütz1, Birgit Rami-Merhar1, Ingrid Schütz-Fuhrmann2,3
1Department of Pediatric and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
Journal of diabetes science and technology
|February 17, 2024
概括
与商业系统相比,开源自动化胰岛素输送 (OS-AID) 系统为1型糖尿病患者提供了优越的血糖控制. 使用OS-AID的用户在范围内获得了更好的时间和更低的HbA1c水平,证明了糖尿病管理的改善,没有安全问题.
科学领域:
- 内分泌学 在内分泌学.
- 生物医学工程 生物医学工程
- 糖尿病 技术 技术
背景情况:
- 自动化胰岛素输送系统 (AID) 在1型糖尿病中显著改善血糖控制.
- 商用MiniMed 670G是奥地利唯一的AID系统,但患者越来越多地采用开源的AID系统 (OS-AID).
- 越来越多的1型糖尿病患者 (PWT1D) 使用OS-AID系统.
研究的目的:
- 评估和比较商业AID系统 (MiniMed 670G) 和OS-AID系统之间的血糖控制质量.
- 使用这些系统进行PWT1D的深入描述性分析.
- 评估不同AID系统在1型糖尿病管理中的有效性.
主要方法:
- 使用MiniMed 670G或OS-AID系统对144个PWT1D进行了3-6个月的回顾性分析.
- 在2020年2月18日至2023年1月15日期间收集的数据.
- 在没有统计测试的情况下进行描述性分析.
主要成果:
- 使用OS-AID的用户在范围内的时间 (TIR) (81.7%与73.9%) 和在范围以上的时间 (TAR) (11.1%与19.6%为181-250 mg/dL) 的时间显著增加.
- 使用OS-AID的患者的平均葡萄糖水平较低 (130比150毫克/分升) 和糖化血红蛋白 (HbA1c) (6.2%比7.0%).
- 低于范围的时间 (TBR) <54 mg/dL在两组之间是相似的 (0.3%对0.4%).
结论:
- 商业和OS-AID系统都能为PWT1D.提供令人满意的血糖结果.
- 与商业MiniMed 670G系统相比,OS-AID系统显示出更好的血糖控制.
- 通过OS-AID系统实现了更好的血糖控制,而不会影响临床安全.
相关概念视频
Insulin Formulations: Types and Delivery
196
Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
Short-acting insulins are divided into...
196
Insulin: Dosing Regimen and Adverse Effects
172
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
172
Diabetes Mellitus: Overview and Type I Subtype
2.6K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.6K
Insulin: Biosynthesis, Chemistry, and Preparation
377
The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
377
Diabetes Mellitus: Type 2 and Gestational
2.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.4K
Diabetes: Management and Pharmacotherapy
283
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
283

