没有乳腺瘤的成年人血清前素水平和死亡率:元分析
Andreas S Papazoglou1, Ana Rita Leite2,3, Dimitrios V Moysidis4
1Cardiology Department, Athens Naval Hospital, Athens 11521, Greece.
The Journal of clinical endocrinology and metabolism
|February 17, 2024
概括
升高的益生菌素 (PRL) 水平与没有益生菌瘤的成年人死亡风险增加有关. 较高的PRL与较大的全因和心血管死亡有关,这表明其作为预后标记物的潜力.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 老年学是指老年学的学科.
背景情况:
- 益生素 (PRL) 是一种具有多种功能的垂体激素.
- 新出现的数据表明,PRL在各种临床环境中可能具有预后价值.
- 它在一般成年人群中死亡风险方面的作用需要进行系统评估.
研究的目的:
- 系统地审查和综合有关血清PRL水平与死亡风险之间的相关证据.
- 量化评估PRL对所有原因和心血管疾病死亡的影响,在没有益生菌瘤的成年人中.
主要方法:
- 进行了全面的文献搜索,截至2023年6月10日.
- 包括了报告PRL水平和没有前乳腺瘤的成年人临床结果的符合条件的研究.
- 随机效应的元分析被用来计算聚合的调整危险比率 (aHR).
主要成果:
- 包括28项涉及23,596人的研究.
- 每个单位的PRL增加都与更高的全因死亡率 (aHR=1.17) 和心血管死亡率 (aHR=1.54) 相关.
- 在最高PRL类别的人群中,所有原因 (aHR=1.81) 和心血管死亡 (aHR=1.59) 的风险显著增加.
结论:
- 血清益乳素水平似乎是死亡率的独立预测指标.
- 需要进一步的研究来验证PRL作为临床风险分层工具的实用性.
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