患有肝硬化和没有肝硬化的患者的酒精相关认知障碍
Bernard Angerville1,2, Marie-Alix Jurdana2, Margaret P Martinetti3
1Filière universitaire d'addictologie, EPS Barthélémy Durand, Étampes, 91150, France.
Alcohol and alcoholism (Oxford, Oxfordshire)
|February 17, 2024
概括
酒精使用障碍 肝硬化患者的认知障碍比没有肝硬化的患者更严重. 需要进一步的研究来了解肝硬化如何影响神经认知缺陷.
科学领域:
- 神经科学是一个神经科学.
- 肝病学 肝病学是一种肝病学.
- 成 药物 药物 药物 药物
背景情况:
- 酒精使用障碍 (AUD) 经常与认知障碍有关,影响高达80%的患者.
- 肝损伤,特别是肝硬化,可能会加剧与酒精有关的神经认知缺陷.
研究的目的:
- 为了比较有肝硬化 (CIR+) 和没有肝硬化 (CIR-) 的AUD患者之间的认知功能.
- 评估肝硬化对酒精相关认知障碍严重性的影响,使用酒精相关神经认知障碍简要评估 (BEARNI) 措施.
主要方法:
- 在一所大学医院的肝病学部门进行了一项前性病例控制研究.
- 82名AUD患者 (50名CIR+,32名CIR-) 使用与酒精有关的神经心理障碍评估 (EAN) 测试进行了评估.
- 各组之间的认知分数进行了比较,根据年龄和教育水平进行了调整.
主要成果:
- CIR+患者的年龄明显大于CIR-患者 (60.1岁与45.5岁相比).
- 在对共变量进行调整后,CIR+患者的平均EAN总得分与CIR-患者相比显著较低 (14.1比7.8).
- 在CIR+患者中,在多个认知领域观察到显著的缺陷,包括延迟的口头记忆,执行功能 (口头流利,交替任务),视觉空间能力和运动协调 (无氧).
结论:
- 患有肝硬化的AUD患者比没有肝硬化的患者表现出更明显的认知障碍.
- 肝硬化似乎是导致AUD认知缺陷严重程度的一个重要因素.
- 建议进行长度研究,以阐明肝硬化进展对AUD认知衰退的影响.
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