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偏磁边缘病变预测了更高的长期复发率和超过10年的临床进展

Jack A Reeves¹, Maryam Mohebbi¹, Taylor Wicks¹

¹Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.

Multiple sclerosis (Houndmills, Basingstoke, England)

|February 17, 2024

概括

偏磁边缘病变 (PRLs) 表明多发性硬化症 (MS) 疾病的侵袭性活动. 这些病变预测更频繁的复发和长期残疾进展,独立于复发.

科学领域:

神经学神经学
放射学放射学是一门学科.
免疫学免疫学免疫学

背景情况:

偏磁边缘病变 (PRL) 与多发性硬化症 (MS) 的疾病严重程度和复发频率增加有关.
对于MS中长期残疾进展的PRLs的预测价值仍然不完全理解.

研究的目的:

确定基线PRL是否预测长期 (10年) 的残疾增加,用扩展残疾状况量表 (EDSS) 来衡量.
评估PRL和长期复发频率之间的关联.
调查复发活动是否调解了PRL和EDSS之间的关系.

主要方法:

对172名多发性硬化症患者 (pwMS) 的回顾性分析,平均随访时间为10.2年,临床访问人数为1868人.
基线3TMRI与定量敏感度映射 (QSM) 用于评估PRLs.
线性模型用于分析PRL,复发率和EDSS变化之间的关联.

主要成果:

与PRL阳性 (PRL+) pwMS相比,PRL阳性 (PRL-) pwMS的年复发率更高,复发几率是PRL阴性 (PRL-) pwMS的三倍.
在PRL+ pwMS中,每年EDSS变化率显著提高.
增加的PRL数与更高的不依赖复发活动 (PIRA) 的进展几率相关.
调解分析显示,与PRL存在相关的EDSS增加的96.7%是独立于复发数的.

结论:

在MS中,PRLs作为攻击性,持续的炎症活动的生物标志物.
PRL表明未来复发频率增加和长期残疾进展,独立于复发.

关键词:

长期活跃的病变慢性活跃的病变扩展的残疾状况规模.铁边缘损伤铁边缘损伤多发性硬化症多发性硬化症偏磁边缘损伤损伤偏磁边缘损伤进展独立于复发活动的进展.这是一个复发的复发.

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