在45-85岁的中国人口中,代谢概况与发生性CKD之间的关联
Bowen Zhu1,2,3, Yiqin Shi1,2,3, Nana Song1,2,3
1Department of Nephrology, Zhongshan Hospital, Fudan University, No.180 Fenglin Road, Shanghai, 200032, China.
International urology and nephrology
|February 17, 2024
概括
像血清尿酸和身体圆度指数这样的代谢和人体指数预测中国成年人的慢性病 (CKD). 综合这些因素的综合分数可以改善CKD的预测.
科学领域:
- 代谢健康和慢性疾病流行病学.
- 用于评估功能的生物标志物.
- 公共卫生中的人类计量措施
背景情况:
- 慢性病 (CKD) 构成了全球健康的重大负担.
- 对发生的CKD代谢和新型人体指数的预测作用需要进一步研究.
- 了解这些预测因素对于在不同人群中早期发现和管理CKD至关重要.
研究的目的:
- 调查新陈代谢和新型人体指数对CKD发病率的综合影响.
- 在中国成年人群中确定CKD的关键预测因子.
- 开发和验证一个复合得分,以提高CKD风险预测.
主要方法:
- 使用中国健康与退休长度研究 (CHARLS) (2011-2015) 数据进行的前性队列研究.
- 包括1825名男性和2218名女性,年龄在45-85岁之间.
- CKD定义为估计的膜过率 (eGFR) < 60 mL/min/1.73 m2.
主要成果:
- 在5年的随访期间,3.0%的男性和4.1%的女性患有CKD.
- 慢性瘤的独立预测因素包括男性的高甘油三,低的HDL-C,血清尿酸 (sUA),内脏脂肪指数 (VFI),身体形状指数 (BSI) 和身体圆度指数 (BRI);女性的sUA和BRI.
- 综合得分包括sUA,心血管疾病史,腰围,HDL-C和BRI (男性) 或sUA,高血压和BRI (女性) 准确预测CKD.
结论:
- 男性的TG,sUA,BSI,BRI升高和HDL降低,女性的sUA和BRI升高与发生的CKD有关.
- 一个综合得分整合疾病史,代谢和新型人体指数有效区分患有和没有发生CKD的个体.
- 这个综合分数为CKD护理和管理提供了有价值的工具.
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