在患有MAFLD的2型糖尿病患者中,晚期肝纤维化和骨质疏松症之间的关系
Binjing Pan1, Yangting Zhao1, Chongyang Chen1
1The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Endocrine
|February 17, 2024
概括
在2型糖尿病患者中,与代谢相关的脂肪肝疾病与较低的骨矿物质密度和较高的骨质疏松症风险有关. 骨密度下降表明肝纤维化风险增加.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 与代谢相关的脂肪肝疾病 (MAFLD) 是2型糖尿病 (T2DM) 患者日益关注的问题.
- 骨质疏松症是T2DM中常见的并发症,其特点是骨矿物质密度 (BMD) 降低.
- 在MAFLD中晚期肝纤维化和T2DM患者骨质疏松症之间的关系仍然不完全理解.
研究的目的:
- 在T2DM患有MAFLD的患者中研究晚期肝纤维化和骨质疏松症之间的关联.
- 为了比较BMD水平和骨质疏松症在MAFLD患者肝纤维化不同阶段的患病率.
主要方法:
- 分析了1144名T2DM患者的队列,将他们分为MAFLD和非MAFLD组.
- 根据非酒精性脂肪肝纤维化评分 (NFS),根据纤维化严重程度 (N1,N2,N3) 分层MAFLD患者 (n=460).
- 测量了BMD,并评估了骨质疏松症的流行率. 患者还被按腰椎BMD三角形 (T1-T3) 分组,以评估纤维化患病率.
主要成果:
- 与非MAFLD患者相比,患有MAFLD的T2DM患者在腰椎和部表现出较低的BMD.
- 晚期纤维化 (N3) 与男性明显较低的BMD和更高的骨质疏松症患病率有关.
- 骨质量水平与NFS有负相关性,表明骨密度较低,肝纤维化严重程度增加.
结论:
- 在患有MAFLD的T2DM患者中,减少的BMD与晚期肝纤维化有显著的相关性.
- 患有MAFLD的老年男性和绝经后女性的骨矿物质密度较低表明肝纤维化风险增加.
- 这些发现突出了骨健康和肝病进展在这个患者群体之间的潜在联系.
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