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构建和验证用于预测患有分化甲状腺癌的儿科和青少年侧面淋巴结转移的诺姆图

Jiaqiang Dan¹, Jingya Tan², Yao Guo¹

¹Geriatric Diseases Institute of Chengdu/Cancer Prevention and Treatment Institute of Chengdu, Department of Thyroid and Breast Surgery, Chengdu Fifth People's Hospital (The Second Clincal Medical College, Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine), NO.33 Ma Shi Street, Wenjiang District, Chengdu, 611137, China.

|February 17, 2024

概括

这项研究确定了儿科分化甲状腺癌 (DTC) 横向淋巴结转移 (LNM) 的关键风险因素,并开发了一个预测性名录. 该模型有助于临床医生评估年轻DTC患者个性化治疗策略的LNM风险.

科学领域:

内分泌学在内分泌学.
儿科瘤学儿科瘤学
手术瘤学手术瘤学

背景情况:

关于儿科和青少年分化甲状腺癌 (DTC) 的横向淋巴结转移 (LNM) 风险因素和预测模型的研究有限.
在DTC患者中,LNM与更差的预后有关.

研究的目的:

确定儿科和青少年DTC中横向LNM的临床风险因素.
在这个人群中开发和验证LNM的预测名录.

主要方法:

来自SEER数据库 (2000-2020年) 的2631名儿科和青少年DTC患者和来自附属医院的339名患者 (2010-2020年) 的回顾性分析.
分析了临床特征,以确定LNM的显著预测因素.
使用已识别的变量构建了一个名图,并通过内部和外部验证.

主要成果:

年龄,瘤大小,多焦点和甲状腺外侵袭显著与侧面LNM有关.
开发的名图表显示出良好的区别 (C指数:0.731,验证的C指数:0.721/0.712).
决策曲线分析证实了名图的临床实用性.

结论:

一个经过验证的nomogram有效地预测了儿科和青少年DTC患者的横向LNM.
该模型利用关键的临床变量来帮助医疗保健从业者在临床决策中.
该工具支持年轻DTC患者的个性化治疗策略.

关键词:

有差异化的甲状腺癌.淋巴结转移是淋巴结的转移.这个名字叫做Nomogram.儿科和青少年的治疗.塞尔 (Seer) 是一个明星.

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