来自植物的神经退行性疾病治疗化合物的综合审查
Dhaya Shankaran Panneerselvam1, Abinaya Kanakaraja1, Meenakumari Sakthivelu1
1Department of Biotechnology, School of Bioengineering, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, 603203, Tamil Nadu, India.
Current medicinal chemistry
|February 17, 2024
概括
植物衍生化合物通过对抗氧化压力来治疗神经退行性疾病 (NDD) 是有前途的. 本综述探讨了来自植物的治疗代谢物,提供了对新型基治疗NDDs的见解.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 植物化学 植物化学
背景情况:
- 神经退行性疾病 (NDD) 是一组影响神经系统的疾病,其特点是蛋白质聚合,氧化应激和炎症.
- 像阿尔茨海默氏症和帕金森症这样的常见NDD影响全球数百万人,预计病例将增加.
- 氧化应激是神经退行的一个关键因素,这表明抗氧化剂是潜在的治疗策略.
研究的目的:
- 审查具有神经保护作用的植物治疗化合物和代谢物.
- 探索植物性抗氧化剂在治疗或预防神经退行性疾病方面的潜力.
- 为未来的研究方向提供见解,包括用于NDD的基于的治疗方法.
主要方法:
- 科学文章的文献评论,重点是植物衍生化合物和神经保护.
- 对植物化学查数据和对抗氧化剂和神经保护作用的研究进行分析.
- 在神经退行症的背景下,研究植物代谢物的作用机制.
主要成果:
- 植物是生物活性分子的丰富来源,具有重要的神经保护潜力.
- 植物衍生化合物,特别是抗氧化剂,可以对抗与NDD相关的细胞氧化应激.
- 这些化合物具有对神经健康有益的多种分子功能.
结论:
- 基于植物的疗法为预防和治疗神经退行性疾病提供了一个有希望的途径.
- 植物代谢物的抗氧化剂和其他分子活动对于它们的神经保护作用至关重要.
- 未来的研究应该考虑用于NDD管理的植物衍生基疗法.
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