泰尔米沙坦加载热敏水凝修复肠上皮屏障,以缓解炎症性肠病
Lu Xu1, Qin Zhao2, Yiqiong Xie1
1Department of Pharmacy, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province 210008, China.
Colloids and surfaces. B, Biointerfaces
|February 17, 2024
概括
泰尔米沙坦水凝通过修复肠道屏障,有效治疗炎症性肠病 (IBD). 这种直肠疗法可以减少结肠损伤和炎症.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 生物医学工程 生物医学工程
背景情况:
- 炎症性肠病 (IBD) 的发病包括肠道屏障功能障碍和炎症.
- 氨酸- ангиотензин系统,特别是 angiotensin II受体1型 (AT1R),影响IBD的进展.
- 目前的IBD治疗在有效性和管理方面面临挑战.
研究的目的:
- 开发和评估一个热敏水凝装载Telmisartan (Tel) 用于IBD的直肠注射.
- 调查特尔米沙坦在修复肠道屏障和缓解大肠炎方面的潜力.
- 评估水凝对持续药物输送和减少直肠刺激的特性.
主要方法:
- 构建一个热敏水凝,用于直肠输送Telmisartan.
- 将 Tel 装载的水凝给大肠炎小鼠模型.
- 评估结肠组织学,肠道屏障完整性 (紧密结合蛋白) 和疾病严重程度.
主要成果:
- 水凝在体温下表现出快速凝,使肠道保持时间长.
- 泰尔米沙坦治疗显著改善了结肠缩短,加厚和炎症细胞透.
- 紧结蛋白的表达被上调,这表明肠道屏障的修复.
- 在接受治疗的小鼠中,性结肠炎疾病的进展得到了缓解.
结论:
- 装有特尔米沙坦的热敏水凝是一种有前途的直肠疗法,用于炎症性肠病.
- 这种方法有效地修复了肠道屏障损伤,并减少了炎症.
- 水凝配方增强了药物保留和IBD治疗的耐受性.
相关概念视频
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
137
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
137
01:29Drugs for Treatment of Ulcerative Colitis in IBD
141
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
141
01:21Inflammatory Bowel Disease V: Surgical Management
145
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
145