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睡眠-觉醒依赖的海马调节恐惧记忆

Yujun Wen¹, Jinhong Jiang², Feng Zhai³

¹Ningxia Key Laboratory of Craniocerebral Diseases, Department of Anatomy, Histology and Embryology, School of Basic Medicine, Ningxia Medical University, Yinchuan, China; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, USA.

|February 17, 2024

概括

海马 (HPC) 调节恐惧记忆. 快速眼神睡眠的HPC巩固了恐惧的灭绝,而清醒的HPC损害了它,在记忆处理中发挥了相反的作用.

科学领域:

神经科学是一个神经科学.
睡眠研究睡眠研究
记忆的巩固记忆的巩固

背景情况:

海马 (HPC) 对于恐惧学习和记忆至关重要.
之前的研究表明,REM睡眠降低了恐惧记忆的巩固,并通过HPC促进了灭绝.
背部和腹部HPC的差异性作用,以及在恐惧记忆中的唤醒与REM睡眠HPC之间的差异性作用仍然不清楚.

研究的目的:

调查背部和腹部HPC在恐惧记忆中的不同作用.
阐明HPC在清醒和REM睡眠期间的功能如何对恐惧记忆产生不同影响.
了解REM睡眠HPC调节恐惧记忆巩固和灭绝的机制.

主要方法:

在REM睡眠期间对HPC及其 afferent entorhinal皮层的化学遗传刺激.
超母细胞核 (SUM) 的化学遗传刺激以诱导HPC激活的觉醒.
给定desipramine (DMI) 来选择性地消除REM睡眠.

主要成果:

快速眼神睡眠 HPC 激活巩固恐惧灭绝记忆.
在REM睡眠期间的背部HPC (dHPC) 刺激通过增强灭绝和减少巩固,显著降低了恐惧记忆.
唤醒HPC激活,由SUM刺激引起,恐惧灭绝受损.
消除REM睡眠,破坏恐惧的灭绝.

结论:

在调节恐惧记忆方面,HPC至关重要.
快速眼神睡眠 HPC 促进恐惧灭绝记忆巩固.
唤醒HPC损害了恐惧的灭绝.
背部和腹部HPC,以及觉醒与REM睡眠HPC在恐惧记忆调节中表现出相反的作用.

关键词:

脑内内皮层 (entorhinal cortex) 是一个内脑皮层.恐惧灭绝灭绝的恐惧在海马体内,海马体中部前额叶皮层中部前额叶皮层.快速眼球运动睡眠快速眼球运动睡眠醒来,醒来,醒来,醒来,这是一个很大的问题.

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