卵巢癌治疗期间的营养干预:对未来研究进行叙述性审查和建议
Sarah Benna-Doyle1, Brenton J Baguley1, Erin Laing2
1Institute for Physical Activity and Nutrition, Deakin University, Locked Bag 20001, Geelong, VIC 3220, Australia.
Maturitas
|February 17, 2024
概括
对于卵巢癌患者的营养干预可以改善结果,但需要更多的研究. 解决营养不良和肌肉损失对于提高治疗有效性和生存率至关重要.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 临床研究 临床研究
背景情况:
- 卵巢癌经常在晚期被诊断出,导致营养不良和肌肉损失,分别高达70%和40%的患者.
- 侵袭性治疗和严重的副作用进一步影响了营养状况,增加了下降的风险.
- 营养不良和肌肉损失是卵巢癌管理中的关键,可修改的预后因素.
研究的目的:
- 审查卵巢癌治疗期间营养干预的证据.
- 评估这些干预措施对营养状况,肌肉质量和临床结果的影响.
- 发现当前研究中的差距,并强调未来研究的必要性.
主要方法:
- 对评估卵巢癌治疗妇女营养干预措施的研究进行系统审查.
- 分析结果,包括营养状况,肌肉质量,症状负担,生活质量和生存率.
- 评估干预类型,如术后免疫营养,营养咨询,运动,口服营养补充剂和营养教育.
主要成果:
- 术后免疫营养对术后的结果产生了不同的结果.
- 预康复计划中的个性化营养咨询有希望,但受到小样本规模的限制.
- 营养咨询与运动相结合是可以接受的,并在化疗期间改善饮食摄入量和生活质量.
- 口服营养补充剂和教育可以减少症状负担.
- 治疗期间的个性化营养咨询表明生存率有所改善,尽管证据来自单一的回顾性研究.
结论:
- 尽管在卵巢癌中营养不良和肌肉损失的发病率很高,但对营养干预的研究是有限的.
- 目前的证据表明,各种营养策略,包括咨询和补充剂的潜在益处.
- 迫切需要进行足够强大的前性研究,以确定营养干预措施的有效性,以优化卵巢癌管理.
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