探索vismodegib:一个非手术的突破在管理先进的周期性基底细胞癌的管理
Georgios Lavasidis1, Argyrios Tzamalis2, Ioannis Tsinopoulos2
1MSc Ocular Surgery, School of Medicine, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece; Evidence-based Medicine Unit, Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, University Campus, 45110 Ioannina, Greece; Department of Ophthalmology, Elpis General Hospital of Athens, Dimitsanas 7, 11522 Athens, Greece.
Cancer treatment and research communications
|February 17, 2024
概括
维斯莫德吉布有效地治疗晚期骨干细胞癌 (BCC),显示出良好的反应率和改善生活质量. 需要进一步的随机试验来确认其在管理这一具有挑战性的眼部癌症方面的全部潜力.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 眼科医生 眼科 眼科
背景情况:
- 周眼基底细胞癌 (BCC) 由于其在眼睛附近的解剖位置而带来管理挑战.
- 维斯莫迪吉布是一种刺路径抑制剂,是治疗高级和转移性BCC的治疗选择.
研究的目的:
- 系统地审查vismodegib对周期性BCC的疗效和安全性.
- 批判性地评估对这种特定BCC亚型的vismodegib治疗现有证据.
主要方法:
- 对观察性和实验性研究进行系统审查.
- 包括37项涉及435名患者的试验.
- 不包括随机对照试验.
主要成果:
- 完全和整体临床响应率分别在20-88%和68-100%之间.
- 在多达14%的病例中观察到疾病进展,复发率从0%到31%不等.
- 常见的副作用包括肌肉,,减肥和脱发;与健康有关的生活质量有所改善.
结论:
- 维斯莫迪吉布在晚期周期性BCC中显示出显著的疗效和可接受的安全性概况.
- 它代表了一种有价值的治疗选择,改善了患者的生活质量.
- 进一步的随机对照试验对于充分阐明其长期潜力和最佳使用至关重要.
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