在接触含有安非他命的血液后,对安非他命在头发中的扩散进行评估
Nathalie Tscheiller1, Elodie Marchand2, Elise Pape3
1Université de Lorraine, CHRU-Nancy, Service de Pharmacologie Clinique et Toxicologie, F-54000 Nancy, France.
Forensic science international
|February 17, 2024
概括
外部接触含有胺类刺激剂的血液可以在几个小时内污染头发. 对这些药物的头发分析需要仔细解释,因为可能存在外部污染风险.
科学领域:
- 法医毒理学 法医毒理学
- 分析化学 分析化学
背景情况:
- 胺类兴奋剂 (ATS) 在全球被广泛滥用.
- 头发分析在法医毒理学中至关重要,但容易受到外部污染.
- 之前的研究还没有完全阐明来自外部血液暴露于ATS的头发污染的程度.
研究的目的:
- 调查胺 (AMP),甲基胺 (MET),MDMA,MDEA和MDA对头发的潜在污染.
- 在外部暴露于ATS刺血液后,量化头发污染水平.
- 评估ATS度和接触时间对头发污染的影响.
主要方法:
- 头发样本暴露在血液中,血液中含有AMP,MET,MDMA,MDEA或MDA,其度各不相同 (22000 ng/mL).
- 暴露时间在室温或4°C下从6小时到14天不等.
- 头发样本经过广泛的洗,然后通过UPLC-MS/MS进行分析.
主要成果:
- 从与所有测试的ATS接触6小时后检测到头发污染.
- 甲基胺显示了最高的污染潜力,可能是由于其极地表面积较低.
- 污染水平与血液中的ATS度相关,在有毒血液度时达到法医切断值.
结论:
- 外部血液暴露可能导致头发受到ATS的严重污染.
- 法医解释的头发药物测试必须考虑外部污染的可能性.
- 需要进行进一步的研究,以建立可靠的方法来区分外部污染与系统性纳入.
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