围绕抗微生物药物的使用在患者管理与体外膜氧化管理的实践:一个国际调查调查
Atul Dilawri1, Justin Muir1, Daniel Brodie2
1Department of Pharmacy, NewYork-Presbyterian Hospital, New York, NY, United States of America.
Journal of critical care
|February 17, 2024
概括
在身体外膜氧化 (ECMO) 的重症患者的抗菌剂剂量策略与非ECMO的抗菌剂量策略没有显著差异. 需要进一步的研究来指导ECMO剂量.
科学领域:
- 关键护理医学 关键护理医学
- 药理学 药理学是指药理学的学科.
- 身体外膜氧化器的氧化
背景情况:
- 危急病患者的抗菌剂剂量因生理障碍而具有挑战性.
- 身体外膜氧化 (ECMO) 引入了额外的生理复杂性.
- 在ECMO患者中最佳的抗微生物剂量仍然是积极研究的领域.
研究的目的:
- 在接受ECMO治疗的患者中调查临床临床医生关于他们对抗微生物剂量策略的看法.
- 为ECMO患者提供抗菌剂的现行实践和挑战做出描述.
主要方法:
- 2022年10月,一项国际,跨部门的调查被分发给重症医疗学会的会员.
- 该调查重点关注重症患者的抗菌剂剂量考虑,特别强调ECMO支持的抗菌剂.
主要成果:
- 97%的受访者发现,在重症患者中,抗微生物剂量是具有挑战性的.
- 87%的人在给ECMO患者服用抗微生物药物时考虑了物理化学药物特性 (脂性,蛋白结合).
- 在类似严重程度的ECMO支持和非ECMO支持的重症患者之间,在抗菌剂剂量策略中没有发现显著差异.
结论:
- 在ECMO治疗的重症患者的抗菌剂剂量方法与非ECMO治疗的同类患者相比没有显著差异.
- 考虑到ECMO的生理复杂性,这些发现是意想不到的.
- 需要精心设计的研究,以建立基于证据的经验性剂量指导,用于ECMO患者.
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