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便中的二氧化与便中的α-1抗素和calprotectin在年轻健康成年人中具有积极的关联

Christianto Putra¹, Dhimiter Bello¹, Shannon L Kelleher¹

¹Department of Biomedical and Nutritional Sciences, Center for Population Health, University of Massachusetts Lowell, Lowell, MA, United States of America.

|February 17, 2024

概括

长期摄入二氧化 (TiO2 / E171),一种常见的食品添加剂,与健康成年人的肠道炎症和透性增加有关. 便中较高的TiO2水平与肠道疾病标志物升高相关,这表明存在潜在的健康问题.

科学领域:

胃肠病学胃肠病学
毒理学毒理学毒理学
食品科学食品科学食品科学

背景情况:

二氧化 (TiO2/E171) 是一种广泛使用的食品添加剂.
动物研究表明,TiO2暴露可能会破坏肠道平衡,增加透性和炎症.
关于慢性TiO2摄入效应的人类数据有限.

研究的目的:

调查摄入的TiO2/E171与健康成年人肠道炎症和透性之间的关联.
为了比较高和低TiO2暴露的个体之间的肠道健康标志物.

主要方法:

对35名健康成年人的横截面研究.
测量便标记物:calprotectin和lactoferrin (炎症),α-1抗素 (A1AT;通透性). 便标记物:calprotectin和lactoferrin (炎症),α-1抗素 (A1AT;通透性) 的测量.
根据便TiO2含量对参与者进行分层,分为高暴露和低暴露组.

主要成果:

在高TiO2组 (42.7 ± 21.6 mg/dL) 与低TiO2组 (22.8 ± 13.6 mg/dL) 相比,观察到较高的便A1AT水平,P = 0.003.3.
在高TiO2组 (51.4±48.6μg/g) 与低TiO2组 (47.5±63.3μg/g) 的便calprotectin升高,P=0.04.
在便TiO2含量和A1AT度 (β ± SE: 19.6 ± 7.2; P = 0.01) 之间发现了正相关性.

结论:

具有较高便TiO2含量的健康成年人表现出增加的肠道透性和炎症标志物.
研究结果表明,摄入的TiO2与不良肠道健康之间存在潜在的联系.
需要对更大的队列进行进一步的研究,以证实这些观察并评估长期影响.

关键词:

E171 一种食物便中的二氧化.肠道炎症肠道炎症肠道的透性肠道的透性纳米颗粒纳米颗粒

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