情绪稳定剂和抗精神病药物的有效性和不良影响的性别差异:系统性审查
Mete Ercis1, Jorge A Sanchez-Ruiz2, Lauren M Webb3
1Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA; Department of Psychiatry, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Journal of affective disorders
|February 17, 2024
概括
精神疾病治疗中的性别差异还未得到充分研究. 女性可能更受益于抗精神病药物,但副作用增加,需要进一步研究药理动力学.
科学领域:
- 精神病学和药理学 精神病学和药理学
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
背景情况:
- 精神疾病的发病率,症状和过程在性别之间有所不同.
- 人们对精神疾病的性别差异的关注不足,影响了治疗建议.
- 本综述通过检查基于性别的治疗反应和关键精神药物的不良影响来解决这一差距.
研究的目的:
- 系统地审查和总结现有的关于治疗情绪稳定剂和抗精神病药物的治疗反应的性别差异的文献.
- 确定男性和女性在使用这些药物时所经历的不良影响的差异.
- 在精神病学中为性别知情的治疗指南提供基础.
主要方法:
- 根据PRISMA 2020指南进行了全面的系统审查.
- 在主要的生物医学和心理数据库中进行了广泛的文献搜索.
- 包括的研究比较了男性和女性参与者之间的情绪稳定剂或抗精神病药物治疗结果,并使用JBI检查清单进行了偏差评估.
主要成果:
- 包括129份报告,主要涉及抗精神病药物 (115) 治疗精神分裂症和双相情感障碍.
- 有限的研究存在于情绪稳定剂反应的性别差异 (只有四项研究).
- 虽然18项抗精神病药物研究没有发现性别差异,但16项研究表明女性的结果更好,她们也报告了两种药物类别的副作用.
结论:
- 对情绪稳定剂治疗结果的性别差异的研究显著有限.
- 女性可能对抗精神病药物有更好的反应,但面临更高的副作用风险.
- 对药物反应中性别差异的药理动力学和药理动力学基础的进一步调查至关重要.
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