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结核病与易刺激性肠综合征之间的关联:全国性的队列研究
Karl Mårild1, Jonas Söderling2, Benjamin Lebwohl3
1Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg, Sweden; Department of Pediatrics, Pediatric Gastroenterology Unit, Queen Silvia Children's Hospital, Gothenburg, Sweden.
患有乳病 (CD) 的患者在CD诊断之前和长时间后都有显著更高的发病易肠综合征 (IBS) 风险. 这突出了临床意识的关键长期关联.
科学领域:
- 胃肠病学 胃肠病学
- 临床流行病学临床流行病学
- 自免疫性疾病 自免疫性疾病
背景情况:
- 病 (CD) 是一种自身免疫性疾病,由摄入质引发.
- 刺激性肠综合征 (IBS) 是一种常见的功能性胃肠疾病.
- CD和IBS风险之间的关系需要进一步调查.
研究的目的:
- 为了确定患有乳病 (CD) 的患者的刺激性肠综合征 (IBS) 诊断风险.
- 为了比较CD患者与普通人群的IBS发病率.
- 探索CD和IBS诊断之间的时间关系.
主要方法:
- 使用了瑞典全国性组织病理学和注册数据 (2002-2017年).
- 27,262名CD患者与132,922名普通人口对照者进行了匹配.
- 考克斯回归和条件后勤回归分析了IBS风险,对共变量进行调整,并考虑诊断时间.
主要成果:
- 病患者的IBS诊断风险增加了3.11倍 (aHR为3.11,95%CI为2.83-3.42).
- 这种高风险长期存在 (≥10年后的aHR为2.00),并且在CD诊断之前也观察到 (OR为3.62).
- 慢性病患者的持续性小毛病缩与IBS诊断的可能性较低有关.
结论:
- 患有乳病的患者面临着显著增加的刺激性肠综合征的风险.
- 结核病和IBS之间的关联在结核病诊断之前和之后都很明显.
- 对这种长期并发症的认识对于临床实践中有效的患者管理至关重要.
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