胃灼热缓解是胃食道逆流性疾病中药物开发的主要未满足需求:门值分析
Eric D Shah1, Michael A Curley2, Amit Patel3
1Division of Gastroenterology, Michigan Medicine, Ann Arbor, Michigan.
概括
针对胃食道逆流性疾病 (GERD) 的新型竞争性酸阻塞剂 (PCAB) 可以每年为患者和保险公司节省超过3000美元. 这些新的GERD疗法也可能改善生活质量,并对保险公司具有成本效益.
科学领域:
- 胃肠病学 胃肠病学
- 药物经济学 药物经济学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 胃灼热症状是胃食道逆流性疾病 (GERD) 医疗利用的主要驱动因素.
- 目前的GERD管理往往受到保险限制的限制,影响治疗选择.
- 竞争性酸阻断剂 (PCAB) 是正在开发的针对GERD的新疗法类别.
研究的目的:
- 在以价值为基础的医疗环境中对新型GERD疗法进行经济分析.
- 评估PCABs的成本效益与现有治疗和不治疗相比.
- 为工业,保险公司,患者和临床医生协调药物开发激励措施.
主要方法:
- 开发了一个决策分析模型,以比较每日20毫克的诺普拉桑 (PCAB) 与标准质子抑制剂 (PPI) 疗法,并在一年内不接受治疗.
- 临床疗效的评估是基于3期试验的无烧日.
- 针对GERD的医疗保健利用数据来自国家观察性研究.
主要成果:
- 治疗不充分的GERD每年平均为患者花费4443美元,保险公司花费3784美元.
- PCAB有潜力每年为患者和保险公司节省至少3000美元的成本.
- PCABs可以提供每年+0.06的质量调整寿命年收益,并且如果每片价格高达8.57美元,可以为保险公司节省成本,假设有效性与PPI相比.
结论:
- 针对GERD的药物开发应该优先考虑缓解胃烧,以创建一致的成本效益激励措施.
- 作为GERD的具有成本效益的治疗选择,PCAB显示出前景,可能有利于所有利益相关方.
- 经济评估对于指导开发和采用新的GERD疗法至关重要.
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