来自内性真菌Xylaria curta YSJ-5 YSJ-5的塞斯基特和α-皮龙
Shan-Shan Wei1, Jia-Ying Lai1, Chen Chen2
1Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Phytochemistry
|February 17, 2024
概括
研究人员从Xylaria curta YSJ-5内菌中发现了新的化合物. 一种化合物,6--4-甲基-二,显示出强烈的抗菌活性对金黄色葡萄球菌.
科学领域:
- 自然产品化学 自然产品化学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 内生菌,如Xylaria curta YSJ-5,是新生物活性代谢物的丰富来源.
- 阿尔卑斯山草 (Alpinia zerumbet) 是一种已知的植物,可以容纳多种多样化的内菌微生物.
研究的目的:
- 从内生菌菌 Xylaria curta YSJ-5中分离和描述新型化学化合物.
- 评估分离化合物的各种生物活性,包括细胞毒性,抗炎性,α-葡萄糖酶抑制和抗菌作用.
主要方法:
- 化学研究涉及从真菌培养物中提取和分离化合物.
- 使用1D和2D-NMR光谱学,修改的莫舍尔方法,电子圆二元化 (ECD) 计算和单晶X射线衍射的结构阐明.
- 在体外测试以评估细胞毒性,抗炎性,α-葡萄糖酶抑制和抗菌活性.
主要成果:
- 隔离了八种新化合物:五种基基 (xylarcurenes A-E),一种基基 (xylarcurene F) 和两种α-pyrone衍生物 (xylarpyrones A-B),以及八种已知的化合物.
- 化合物6-pentyl-4-methoxy-pyran-2-one对黄金葡萄球菌和耐美西林黄金球菌 (MRSA) 显示出显著的抗菌活性.
- 对抗S. aureus和MRSA的6-pentyl-4-methoxy-pyran-2-one的最小抑制度 (MIC) 确定为6.3微克/毫升.
结论:
- 植物内菌Xylaria curta YSJ-5产生了一系列多样化的新型基类和α-pyrone衍生物.
- 6--4-甲基-二具有强大的抗菌特性,表明其作为开发新抗感染剂的化合物的潜力.
- 需要进一步的研究来探索这些孤立的天然产品的全部治疗潜力.
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