微生物组及其与中国本土炎性肠病的相关性
Anqi Han1, Mingya Yang2, Bo Chen1
1Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China.
Gene
|February 17, 2024
概括
肠道微生物群失生症,包括增加的西格拉菌和减少的益生菌,与中国患者的炎症性肠病 (IBD) 有关. 像Neisseria这样的口腔细菌在IBD中也表现出更高的丰度.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 人类健康 人类健康 人类健康
背景情况:
- 炎症性肠病 (IBD) 是一种慢性胃肠道疾病,其原因尚不清楚.
- 在IBD的发病过程中,人们怀疑肠道失生症,但中国人群中缺乏深度测序和口腔微生物群研究.
研究的目的:
- 研究口腔和肠道微生物群在患有炎症性肠病 (IBD) 的中国患者中的作用.
- 探索口腔/肠道微生物群和IBD之间的潜在关联.
主要方法:
- 收集了80名IBD患者 (69名克罗恩氏病,11名性结肠炎) 和24名对照患者的临床数据,和唾液样本.
- 使用16S rRNA测序和全长16S rRNA测序进行微生物分析.
- 分析了IBD患者和健康对照人群之间微生物组成的差异.
主要成果:
- 在IBD患者表现出更高的肠道Shigella spp. 与对照人群相比,肠道炎症的丰度 (与IBD严重程度相关) 和益生菌 (Prevotella,Faecalibacterium,Roseburia) 的水平较低.
- 在IBD患者中观察到口服内菌的丰度增加.
- IBD患者的炎症标志物增加,肝脏/脏功能受损和脂质失调. 特定的肠道细菌 (CD中的Clostridium,UC中的Ruminococcus) 的含量增加. 口腔和便微生物群有显著差异,但在主导益生菌中显示出一些相关性.
结论:
- 肠道细菌不良和病原性细菌感染,如Shigella,可能与IBD的发展或进展有关.
- 这项研究强调了肠道和口腔微生物群变化与中国队列中的IBD之间的联系.
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