摩达菲尼尔疗法和精神状态后的动脉瘤下结出血:综合性中风中心分析
Stefan W Koester1, Kavelin Rumalla1, Joshua S Catapano1
1Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.
World neurosurgery
|February 17, 2024
概括
莫达菲尼尔改善了从动脉瘤下arachnoid出血 (aSAH) 恢复的患者的精神状态. 这种促进清醒的药物表现出良好的安全性,这表明在急性护理机构的早期使用.
科学领域:
- 神经科学是一个神经科学.
- 临界护理医学 临界护理医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 意识障碍使经历了动脉瘤下关节出血 (aSAH) 后的恢复复杂化.
- 莫达菲尼尔是一种促进清醒的药物,在中风幸存者中有效治疗疲劳.
- 关于modafinil在aSAH患者的急性使用的数据有限.
研究的目的:
- 评估modafinil对aSAH患者精神状态的影响.
- 评估modafinil在aSAH急性护理环境中的安全性和有效性.
主要方法:
- 对aSAH患者中modafinil使用的回顾性分析.
- 记录了modafinil的时间,剂量和患者状态 (神经学检查,输管,治疗).
- 倾向性得分匹配 (1:1) 与modafinil和无modafinil队列进行比较.
主要成果:
- 莫达菲尼尔 (100-200毫克/天) 给了21%的aSAH患者.
- 87.5%的modafinil接受者在72小时内表现出改善.
- 莫达菲尼尔队伍在出院时格拉斯哥昏迷表得分有更大的改善 (P=0.003).
结论:
- 莫达菲尼尔在aSAH患者中显示出与改善精神状态的时间关联.
- 该药物表现出有利的不良影响概况.
- 支持在急性aSAH护理中启动modafinil的低门.
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