作为补充剂,具有内腔结构的新和安全的脱枝粉-复合物具有内腔结构
Kangkang Zhi1, Wenhui Dong1, Yanjing Du2
1College of Life Science, Northwest Normal University, Lanzhou, Gansu 730070, China; Institute of New Rural Development, Northwest Normal University, Lanzhou, Gansu 730070, China.
Carbohydrate polymers
|February 17, 2024
概括
新的破碎粉-复合物 (DS-Zn) 提供了更好的输送. 这些新型补充剂显示了增强的生物可用性和安全性,为缺乏症提供了有希望的解决方案,特别是在儿童中.
科学领域:
- 营养科学 营养科学
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 缺乏症对人类健康和发育构成重大风险,特别是在儿童中.
- 有效的补充对于减轻这些风险至关重要.
- 需要新的输送系统来提高的吸收和有效性.
研究的目的:
- 为了准备和表征脱枝粉-复合物 (DS-Zn) 作为一种新补充剂.
- 评估DS-Zn.的物理化学特性,生物安全性和传递效率.
- 开发一个可口味的口服药片配方,用于儿科.
主要方法:
- 用于制备不同含有氨基素的脱枝粉-复合物 (DS-Zn).
- 使用导电性,XRD,染,热重力测量,XPS,固态13C NMR和IR进行表征.
- 在缺乏细胞模型中的体外消化模拟和评估.
- 评估生物安全性 (血液,细胞,突变性).
主要成果:
- DS-Zn复杂化与氨基氨酸含量成反比例.
- 阐明了DS-Zn的内结构,位于复合体内.
- DS-Zn表现出良好的生物安全性.
- 与无机相比,DS-Zn对胃肠道疾病的耐受性增强,补充剂优异 (33%的增加).
- 可以口服的口服片被成功制备.
结论:
- 脱枝粉-复合物是一种安全有效的新补充剂.
- DS-Zn提供了改善的生物可用性和胃肠道稳定性.
- 这项研究支持了基营养补充剂的开发,特别是针对儿童的营养补充剂.
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