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Updated: Jul 2, 2025

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LncRNAs:在没有蛋白质的情况下发挥影响力的艺术

Lorena Ramírez Gonzales¹, Suze Blom², Rossana Henriques³

¹Plant Breeding, Wageningen University and Research, Wageningen, The Netherlands.

Trends in plant science

|February 17, 2024

概括

植物长非编码RNA (lncRNAs) 正在向功能性研究迈进. 哺乳动物 lncRNA 研究提供了关于植物 lncRNA 功能和潜在农业应用的见解.

科学领域:

分子生物学分子生物学
基因组学就是基因组学.
植物科学植物科学

背景情况:

植物长非编码RNAs (lncRNAs) 的研究领域正在从识别转向功能性特征.
哺乳动物lncRNA研究提供了一个有价值的比较框架,因为保留了相互作用类型和分子功能.

研究的目的:

讨论由lncRNAs调节的分子过程,包括染色体调节和拼接.
探索lncRNA互动组,包括与蛋白质,其他RNA和DNA的相互作用.
假设哺乳动物的 lncRNA 功能如何能为植物研究提供信息,并导致新的发现.

主要方法:

文献综述和对哺乳动物和植物lncRNA功能当前研究的综合.
跨王国保存的 lncRNA 分子机制的比较分析.
基于哺乳动物对应物的潜在植物 lncRNA 功能的假设建模.

主要成果:

lncRNAs参与各种分子过程,从染色质修饰到RNA剪接.
lncRNA相互作用体是复杂的,涉及与蛋白质,RNA和DNA的相互作用.
跨王国保护表明,哺乳动物lncRNA研究可以指导发现植物lncRNA功能.

结论:

了解植物 lncRNA 的生物学作用和应用对于推进农业科学至关重要.
哺乳动物lncRNA研究的突破为发现新型植物lncRNA功能提供了重大潜力.
对植物 lncRNA 的进一步研究可以解锁未来的农业创新.

关键词:

RNA生物学的RNA生物学基因组动力学基因组动力学在ncRNA中,我们可以哺乳动物研究的研究.分子相互作用分子相互作用.

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相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

Ribosomal RNA Synthesis

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...

RNA Interference

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...

Nucleic Acids

Nucleic Acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...