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粘膜宿主-微生物相互作用与炎症性肠病的临床表型有关
Shixian Hu1,2,3, Arno R Bourgonje1, Ranko Gacesa1,2
1Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Nature communications
|February 17, 2024
概括
被破坏的宿主-微生物相互作用是炎症性肠病 (IBD) 的核心. 这项研究揭示了IBD患者的特定基因-微生物联系,突出了微生物群导向疗法的潜在目标.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 在粘膜水平上破坏宿主-微生物相互作用在炎症性肠病 (IBD) 病理生理学中至关重要.
- 了解这些相互作用是开发向治疗的关键.
研究的目的:
- 在IBD患者中全面检查粘膜基因表达和微生物群之间的交叉声.
- 为了确定与疾病亚型和治疗相关的特定宿主微生物相互作用.
主要方法:
- 从IBD患者和对照组的697次肠道活检中进行了转录基因 (RNA-seq) 和微生物 (16S-rRNA-seq) 分析.
- 对转录-细菌相互作用的分析,以确定与特定细菌相关的炎症相关途径.
主要成果:
- 在IBD中,粘膜基因表达受位置和炎症的影响,而微生物群的组成高度个性化.
- 特定的细菌丰度与不同的基因表达模式相关 (例如,具有脂肪酸代谢的Bifidobacterium,具有金属氨酸信号的Bacteroides).
- 与特定细菌相关的明显的转录网络在纤维性克罗恩病和接受TNF-α对抗剂治疗的患者中被确定.
结论:
- 在IBD中存在特定的环境粘膜宿主-微生物相互作用.
- 与炎症相关的基因-分类模块的改变特别明显在纤维细胞瘤患者和服用TNF-α对抗剂的患者中.
- 这些发现支持IBD的微生物向精密医学.
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