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Updated: Jul 2, 2025

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
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Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation

Published on: June 26, 2018

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ангиотензин 1 型受体的激活促进神经元和质细胞的α-synuclein 聚合和传播

Lucia Lage1, Ana I Rodriguez-Perez1,2, Begoña Villar-Cheda1,2

  • 1Cellular and Molecular Neurobiology of Parkinson's disease, Research Center for Molecular Medicine and Chronic diseases (CIMUS), IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain.

NPJ Parkinson's disease
|February 17, 2024
PubMed
概括

大脑氨酸- ангиотензин系统 (RAS) 的过度激活促进了α-synuclein的聚合和扩散,恶化了帕金森病的进展. 阻断血管激素II型1受体 (AT1) 可能提供治疗效益.

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