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碳支持的三元层双氧化物纳米复合材料,用于去除Fluoxetine,并随后利用已耗尽的吸附剂作为抗抑郁药

Samar M Mahgoub¹, Doaa Essam², Zienab E Eldin¹

¹Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef, Egypt.

Scientific reports

|February 17, 2024

概括

一种新型纳米复合材料有效地从废水中去除持久性制药性素 (FLX). 装有FLX的材料 (FLX-LAC) 在老鼠中显示出更高的安全性和更长的睡眠时间,这表明了潜在的治疗益处.

科学领域:

环境化学环境化学
材料科学材料科学材料科学
药理学药理学是指药理学的学科.

背景情况:

由于广泛使用抗抑郁药物,素 (FLX) 是废水中的持续性制药污染物.
从废水中有效地去除FLX对于环境和公共健康至关重要.
目前的治疗方法在完全消除这种持久性化合物方面面临挑战.

研究的目的:

开发和描述一种新的纳米复合材料吸收剂,以有效地从废水中去除素 (FLX).
研究吸附机制并优化去除条件.
评估FLX-吸收复合物 (FLX-LAC) 的安全性和药理作用.

主要方法:

在活性炭 (LAC) 纳米复合材料上支持的三元ZnCoAl层状双氧化物的合成和表征.
吸附研究以确定最佳条件 (pH,剂量,体积,温度) 和吸附动力学 (Langmuir-Freundlich模型).
描述技术包括FTIR,SEM,TEM,XRD和BET表面积分析.
在体内急性毒性和药理学评估 (睡眠时间) 在雄性白色大鼠使用试管分析.

主要成果:

该LAC纳米复合材料的最大吸附能力为450.92mg/g的FLX在pH10,25°C,以及特定的吸附剂剂量和溶液体积.
吸附遵循兰格穆尔-弗朗德利希模型,表明复杂的吸附机制.
密度函数理论 (DFT) 的计算阐明了FLX吸附机制.
与单独使用FLX相比,FLX-LAC (20 mg/kg) 给药显著延长了大鼠的睡眠时间,没有观察到急性毒性.

结论:

开发的LAC纳米复合材料是一种高效的吸附剂,可以从废水中去除素.
与标准的Fluoxetine相比,FLX-LAC显示出作为一种治疗剂的潜力,具有增强的安全性和长时间的镇静作用.
这项研究突出了环境修复和潜在的制药开发的双重应用材料.

关键词:

吸附方式吸附方式吸附方式抗抑郁药是一种抗抑郁药.富洛克塞提因 (Fluoxetine) 是一种药物.消耗的吸收剂已经消耗.有毒性有毒性废水是废水,废水就是废水.

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