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皮肤颜色影响皮肤间胆红素的测量:一个系统的体外评估

Alida J Dam-Vervloet^1,2, Claudia F Morsink³, Marleen E Krommendijk³

¹Biomedical Photonic Imaging group, Technical Medical Centre, University of Twente, Enschede, The Netherlands. a.j.dam@isala.nl.

Pediatric research

|February 17, 2024

概括

通过皮肤测量胆红素 (TcB) 在皮肤较暗的新生儿中被低估. 这项体外研究表明,增加皮肤色素会导致比利鲁宾水平的低估,特别是在更高度时.

科学领域:

新生儿护理和诊断服务
胆红素代谢和监测和监测.
皮肤病学和光生物学

背景情况:

通过皮肤测量胆红素 (TcB) 是诊断新生儿高胆红素血症的标准.
现有的文献提出了关于皮肤颜色对TcB准确性的影响的相互矛盾的发现.
有关可能低估或高估皮肤颜色较暗的婴儿胆红素水平存在担忧.

研究的目的:

系统地评估皮肤颜色对TcB测量的影响.
量化不同黑色素体度对TcB读数的影响.
提供TcB在皮肤色素的频谱的精度的体外评估.

主要方法:

使用胆红素计 (JM-105) 进行测量.
雇佣了模拟新生儿皮肤的分层幻影,控制了胆红素度 (0-250μmol/L).
多种表皮黑色素体体积分数从0%到40%来模仿明亮到深色皮肤色调.

主要成果:

皮肤色素显著影响TcB测量.
增加的黑色素体体积分和更高的胆红素水平导致了对TcB的更大低估.
在体外低估值范围在26-132μmol/L之间,比利鲁宾水平为250μmol/L,对于更深色的皮肤幽灵.

结论:

皮肤颜色明显影响TcB测量准确度,导致低估与增加的色素.
低估效应在比利鲁宾度较高时更加明显.
这些发现强调了需要改进TcB仪表技术,并仔细解释皮肤较暗的婴儿的读数.

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